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Diabesity and sleep apnoea syndrome


Authors: Viliam Donič 1;  Viera Doničová 2
Authors‘ workplace: Ústav lekárskej Fyziológie LF Univerzity Pavla Jozefa Šafárika v Košiciach 1;  Human-Care s. r. o., Interná a diabetologická ambulancia, Košice 2
Published in: Forum Diab 2016; 5(1): 41-44
Category: Topic

Overview

Type 2 diabetes mellitus (DM2T) and obstruction sleep apnoea (OSA) represent a medical problem which involves a wide range of physician specialties. The nature of the pathophysiological mechanism underlying the link between DM2T and OSA is still unclear. Prevalence of OSA among the population ranges from 5–15 %, but incidence of OSA among the patients with DM2T or obese individuals reaches 50–80 %. It is assumed that central obesity and intermittent hypoxia in adipose tissue creates the link between DM2T and OSA. The research into diabesity focuses on the role of adipose tissue and agents released from it. There are tissue cultures and animal models used and clinical studies in humans are conducted. However the results are often contradictory and their interpretation is complicated. The aim of this study is to highlight the role of the factors of obesity and hypoxia connected with by OSA in the pathogenesis of DM2T. It includes the latest theories and hypotheses which try to explain some hitherto hidden links and mechanisms.

Key words:
CPAP – diabesity – hypoxia – insulin resistance – obesity – OSA – DM2T


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Labels
Diabetology Endocrinology Internal medicine
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