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New classes of antidiabetic drugs: DPP4 inhibitors and SGLT2 inhibitors in the treatment of a patient with type 2 diabetes and obesity


Authors: Vladimír Uličiansky
Authors‘ workplace: Via medica, s. r. o.
Published in: Forum Diab 2016; 5(1): 17-22
Category: Topic

Overview

Dipeptidyl peptidase 4 (DPP4) inhibitors (sitagliptin, vildagliptin, saxagliptin, linagliptin, alogliptin) and sodium glucose cotransporter 2 (SGLT2) inhibitors (dapagliflozin, canagliflozin, empagliflozin) are new therapies for type 2 diabetes mellitus. They can be used alone or in combination with other glucose-lowering agents. DPP4 inhibitors exert antihyperglycemic effects by inhibiting DPP4 and thereby enhancing levels of GLP-1. DPP-4 inhibitors are weight neutral. SGLT2 inhibitors have a glucosuric effect that results in decreased HbA1c, weight and systolic BP. The differing modes of actions of these therapies produce varied efficacy and tolerability profiles and additional treatment benefits beyond glycemic control.

Key words:
type 2 diabetes – DPP4 inhibitors – SGLT2 inhibitors – body weight


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Labels
Diabetology Endocrinology Internal medicine
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