Possibilities of using genetic knowledge in type 2 diabetes in clinical practice


Authors: Ivan Tkáč
Published in: Forum Diab 2019; 8(2): 150-152
Category:

Overview

The use of genetic knowledge has been used in the clinical practice of diabetology for several decades. These findings have so far been mainly used in the diagnosis and treatment of monogenic types of diabetes. Although genome-wide association studies have identified more than 100 gene variants associated with type 2 diabetes, the translation of these findings into clinical practice is still limited. In this paper, we present two examples of the transfer of genetic knowledge into clinical practice regarding the pharmacogenetics of metformin therapy and the possibility of using genetic scores to assess cardiovascular risk in patients with type 2 diabetes.

Keywords:

cardiovascular genetic score – genetics of type 2 diabetes – pharmacogenetics of metformin


Sources
  1. Zhou K, Yeah SW, Seiser EL et al. Variation in the glucose transporter gene SLC2A2 is associated with glykemic response to metformin. Nat Genet 2016; 48(9): 1055–1059. Dostupné z DOI: <http://dx.doi.org/10.1038/ng.3632>.
  2. Rathmann W Strassburger K, Bongaerts B et al. [GDS Group]. A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes. Diabetologia 2019; 62(2): 286–291. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–018–4759-z>.
  3. Morieri ML, Gao H, Pigeyre M et al. Genetic tools for coronary risk assesment in type 2 diabetes. A cohort study from the ACCORD clinical trial. Diabetes Care 2018; 41(11): 2404–2413. Dostupné z DOI: <http://dx.doi.org/10.2337/dc18–0709>.
Labels
Diabetology Endocrinology Internal medicine

Article was published in

Forum Diabetologicum

Issue 2

2019 Issue 2

Most read in this issue

This topic is also in:


Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account