Diabetic cardiomyopathy and heart failure


Authors: Ján Murín 1;  Jozef Bulas 1;  Martin Wawruch 2
Authors‘ workplace: I. interná klinika LF UK a UNB, Nemocnica Staré Mesto, Bratislava 1;  Ústav farmakológie a klinickej farmakológie LF UK v Bratislave 2
Published in: Forum Diab 2019; 8(3): 165-169
Category:

Overview

Diabetes mellitus type 2 is a strong cardiovascular risk factor and in the development of heart failure three pathological factors or diseases play important role: ischemic heart disease, cardiomyopathy and autonomic cardiac neuropathy. Analysis of the development of diabetic cardiomyopathy is presented in this article: epidemiology of this disease, pathological mechanisms of this disease development (hyperglycemia, oxidative stress, vascular inflammation, myocardial metabolism malfunction, cardiac remodeling, perfusion abnormalities),screening of this cardiomyopathy (imaging modalities, biomarkers, exclusion of presence of myocardial ischemia) and also treatment possibilities (treatment of diabetes and of risk factors, adjustment of metabolism, and improvement of myocardial function). When we understand the development of diabetic cardiomyopathy, then we can intervene with this problems in prevention and in the treatment.

Keywords:

diabetes mellitus type 2 – diabetic cardiomyopathy – heart failure – treatment of diabetic cardiomyopathy


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Diabetology Endocrinology Internal medicine
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