Dulaglutide and cardiovascular outcomes in patients with type 2 diabetes: REWIND study


Authors: Ivan Tkáč
Authors‘ workplace: IV. interná klinika UPJŠ LF a UNLP Košice
Published in: Forum Diab 2019; 8(3): 208-211
Category:

Overview

In the REWIND study, the effect of GLP1 receptor agonist (GLP1RA) dulaglutide vs. placebo on prevention of cardiovascular event was compared as an add-on therapy in patients with type 2 diabetes. This study included the lowest risk population of patients with type 2 diabetes among the studies with GLP1RA so far, since only 31% of the enrolled patients had had previous cardiovascular disease. Dulaglutide given once weekly significantly reduced the incidence of the primary outcome – major cardiovascular events by 12%, and of stroke by 24%. The composite renal outcome reflecting the progression of chronic kidney disease was also significantly reduced by 15%. Thus, in the REWIND study, the previous positive results of GLP1RA studies were replicated in a significantly less at-risk population, since in the previous studies the proportion of patients with previous cardiovascular disease was greater than 75%. Due to their anti-atherogenic effect, treatment with GLP1RA is indicated not only in diabetics with previous cardiovascular diseases but also in diabetics at very high or high cardiovascular risk.

Keywords:

cardiovascular disease – dulaglutide – GLP1 receptor agonists – type 2 diabetes


Sources
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Labels
Diabetology Endocrinology Internal medicine
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