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Obesity, diabetes mellitus and cardiovascular disease: dangerous metabolic triad

Czech version

Authors: Ubomíra Fábryová 1,2
Authors‘ workplace: Metabol KLINIK, s. r. o. – Ambulancia pre diabetológiu, poruchy látkovej premeny a výživy, Špecializovaná lipidologická ambulancia, MED PED centrum, Bratislava 1;  Biomedicínske centrum SAV, Bratislava 2
Published in: Forum Diab 2019; 8(3): 178-183
Category: Review Article

Overview

Obesity and type 2 diabetes mellitus are chronic, preventable, relapsing and the most common metabolic diseases that currently reach the dimensions of the epidemic (pandemic). It affects not only adults but also children and ado­lescents. In most European countries, the prevalence of overweight and obesity is around 50% in the adult population and is responsible for developing up to 80% of cases of type 2 diabetes, resulting in increased morbidity and mortality. Diabesity is becoming a huge problem, not only health, but also social and economic. At the population level, there is no doubt that overweight / obesity/diabesity is very closely related to the increase in cardiovascular morbidity and mortality associated with shortening life expectancy. Obesity/diabesity is mainly associated with the development of atherosclerosis-related cardiovascular diseases, including coronary artery disease, peripheral arterial disease, stroke, atrial fibrillation. However, patients with type 2 diabetes have a greater than 3-fold increase in the risk of heart failure. Currently, we understand the prevention of overweight/obesity as a parallel prevention of the development of type 2 diabetes and other chronic cardio metabolic, cancer and some neurodegenerative diseases. However, from a complex perspective it should be noted that obesity is often associated with an improvement in survival in some cardiovascular diseases, which led to the creation of the term “paradox of obesity”.

Keywords:

obesity – adiposopathy – adiposopathic dyslipidemia – cardiovascular diseases – diabesity – ectopic adipose tissue – heart failure – obesity paradox – type 2 diabetes mellitus

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Labels
Diabetology Endocrinology Internal medicine
Diabetic cardiomyopathy and heart failure
What is actually the cardiovascular risk related to type 2 diabetes?
Cardiorenal syndrome and gliflozins
The role of a fixed-ratio titratable combination of iGlarLixi in type 2 diabetes mellitus therapeutic regimen
The EMPRISE study (Real World Evidence): empagliflozin is reducing number of hospitalizations for heart failure, even in patients without cardiovascular disease
Cardiovascular studies and gliflozins
Dulaglutide and cardiovascular outcomes in patients with type 2 diabetes: REWIND study
Continuous monitoring of blood glucose in diabetes mellitus management – aid in individualization of treatment
Article was published in

Forum Diabetologicum

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2019 Issue 3
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