What is actually the cardiovascular risk related to type 2 diabetes?


Authors: Ivan Tkáč
Authors‘ workplace: IV. interná klinika UPJŠ LF a UNLP Košice
Published in: Forum Diab 2019; 8(3): 170-173
Category:

Overview

Cardiovascular risk assessment by SCORE tables is used in subjects without diabetes. Even the latest recommendations of the European Cardiology Society (ESC) assess the cardiovascular (CV) risk in patients with based on the expert consensus and not on the basis of the risk calculated from the tables. The paper demonstrates the risk of developing major CV events and CV mortality observed in studies with SGLT2 inhibitors and GLP1 receptor agonists. In all studies where an effect on the primary composite outcome was observed, the 10-year risk of CV mortality was greater than 10 % and the risk of developing major CV events was greater than 25 %, which corresponds to a very high SCORE risk. The closest to the characteristics of the so-called general population of patients with diabetes in clinical practice was that of the REWIND study that compared add-on therapy with a GLP1 receptor agonist dulaglutide with placebo.

Keywords:

cardiovascular risk – clinical studies – GLP1 receptor agonists – SGLT2 inhibitors – type 2 diabetes


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Labels
Diabetology Endocrinology Internal medicine
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