Hypolipidemic treatment in the prevention of atherosclerosis in diabetic patients


Authors: Ľubomíra Fábryová 1,2,3
Authors‘ workplace: MetabolKLINIK s. r. o., Ambulancia pre diabetológiu, poruchy látkovej premeny a výživy, MED PED centrum, Bratislava 1;  Biomedicínske centrum Slovenskej Akadémie Vied, Bratislava 2;  Ústav zdravotníckych disciplín, Vysoká škola zdravotníctva a sociálnej práce sv. Alžbety, Bratislava 3
Published in: Forum Diab 2021; 10(Suplement 1): 28-36
Category:

Overview

Diabetes mellitus is a major cardiometabolic disease and is one of the main causes of premature development of atherosclerosis-related cardiovascular disease (AS CVD) in both sexes: myocardial infarction, stroke, need for revascularization and peripheral vascular disease. The incidence of cardiovascular diseases is high in type 2 diabetic patients in Slovakia (approximately 37 %) and is higher compared to Europe (30 %) as well as the world (32.2 %). The development of AS CVD in diabetics is conditioned not only by glycemic compensation, the duration of the disease, but especially by the presence of coexisting risk factors, including lipid and lipoprotein metabolism disorders. Current clinical practice should focus on more aggressive hypolipidemic treatment of high-risk diabetic patients in order to reduce CV morbidity and mortality. The review article provides an overview of our current possibilities of hypolipidemic therapy in diabetic patients, as well as hypolipidemic therapy in the near future.

Keywords:

bempedoic acid – cardiovascular risk categories – diabetic dyslipidemia – ezetimibe – fibrates – inclisiran – omega 3 fatty acids – PCSK9 inhibitors – pemafibrate – primary and secondary targets – statins


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Labels
Diabetology Endocrinology Internal medicine
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