Cardiovascular and renal prognosis depends also on glycemic state

Authors: Ján Murín
Authors‘ workplace: I. interná klinika LF UK a UNB, Nemocnica Staré Mesto, Bratislava
Published in: Forum Diab 2022; 11(1): 56-59
Category: News


Treatment guidelines for pre-diabetes focus primarily on glycemic control and lifestyle management. Cardiovascular (CV) and renal outcomes of these patients is also dependent on their glycemic state. The UK Biobank is a prospective, observational, population-based cohort of adult residents in UK, who were 40–69 years old at the time of recruitment between 2006–2010. Among 336 709 individuals (mean age 56.3 ys, 55.4% female) an association of glycemic state (type 2 diabetes, T2D, in 12 717 patients, 3.8%; pre-diabetes in 46 911 patients, 13.9% and normoglycemic persons in 277 081, 82.3%) with outcomes (CV disease, chronic kidney disease, CKD and heart failure, HF) was tested (Cox model) over median of follow-up of 11.1 years. Pre-diabetes and T2D independently associated with CV disease (pre-diabetes with relative risk, RR, 1.11, S and T2D with RR 1.44, S), with CKD (pre-diabetes with RR 1.08, S and T2D with RR 1.57, S) and with HF (pre-diabetes with RR 1.07, S and T2D with RR 1.25, S). Pre-diabetes and T2D are associated with CV disease, with CKD and with HF. These finding highlight the need to design risk-reduction strategies across the glycemic spectrum.


heart failure – cardiovascular disease – type 2 diabetes – chronic kidney disease – pre-diabetes – prognosis of pre-diabetes and type 2 diabetes


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