Hyperuricemia and diabetes mellitus


Authors: Peter Jackuliak;  Juraj Payer
Authors‘ workplace: V. interná klinika LF UK a UNB, Nemocnica Ružinov, Bratislava
Published in: Forum Diab 2019; 8(1): 15-20
Category:

Overview

Hyperuricemia, an abnormally high level of uric acid, often occurs in patients with type 2 diabetes mellitus (T2DM). Based on various studies, there is an evidence of association between elevated uric acid levels and an increased risk of T2DM development, even in younger patients. Hyperuricemia also occurs often in patients with metabolic syndrome. Examination of uric acid levels is particularly important in terms of assessing the cardiovascular risk of diabetic patients. It has been shown, that higher levels of uric acid are associated with increased cardiovascular mortality, worsening prognosis of diabetic complications. Generally serum level of uric acid > 8 mg/dl (> 480 μmol/l) is considered to be a value for initiating risk assessment in patients with asymptomatic hyperuricemia, including diet, change of lifestyle, and/or pharmacotherapy. Xanthine oxidase inhibitors are used in pharmacotherapy of hyperuricemia. From antidiabetic drugs, the newest group – SGLT-2 inhibitors – have proven effect for lowering of uric acid levels.

Keywords:

diabetes mellitus – hyperuricemia – insulin resistance – metabolic syndrome


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Diabetology Endocrinology Internal medicine
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