Diabetes mellitus and chronic heart failure


Authors: Tomáš Bolek;  Matej Samoš;  Jakub Benko;  Jakub Jurica;  Martin Jozef Péč;  Marek Cingel;  Marián Mokáň
Authors‘ workplace: I. interná klinika JLF UK a UNM, Martin
Published in: Forum Diab 2021; 10(3): 173-179
Category:

Overview

Patients with diabetes mellitus (DM) have 2–4 times higher risk to develop heart failure, and a 1 % increasing in glycated hemoglobin (HbA1c) increases the risk of heart failure by 8–36 %. There is evidence that more than 60 % of patients with heart failure have developed insulin resistance. Therefore, DM and heart failure is often linked. There were many studies related to treatment in patients with chronic heart failure with reduced systolic function (HFrEF). Moreover, therapy with sodium-glucose-transporter 2 inhibitors (SGLT2i) has brought a clear benefit in diabetics with HFrEF, but also in patients without DM. However, nowadays, there are a relatively small number of published studies that would evaluate the efficacy of treatment in diabetics with chronic heart failure with moderate reduced (HFmrEF) and preserved left ventricular ejection fraction (HFpEF). In this article, we would like to review the “evidence gap” in the issue of heart failure in patients with DM.

Keywords:

diabetes mellitus – chronic heart failure


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