Apixaban in patients with diabetes mellitus and atrial fibrillation

Authors: Matej Samoš;  Tomáš Bolek;  Martin Jozef Péč;  Marián Mokáň
Authors‘ workplace: I. interná klinika JLF UK a UNM, Martin
Published in: Forum Diab 2022; 11(2): 94-97


Apixaban is a new generation, oral, highly selective, direct and reversible inhibitor of activated coagulation factor X (FXa) which belongs to the group of direct oral anticoagulants (DOAC). Atrial fibrillation (AFib) is in patients with diabetes mellitus (DM) associated with higher risk of embolic events and long-term anticoagulation therapy is needed in majority of patients with DM and AFib to prevent these events. According to current recommendations, DOAC should be preferred for prevention of embolic events in patients with AFib. The question is whether there are currently sufficient data available regarding the efficacy and safety of apixaban therapy in patients with DM, and whether the presence of DM affects apixaban plasma levels and clinical effect of apixaban therapy. This article summarizes currently available data about the apixaban therapy in patients with DM and AFib.


atrial fibrillation – diabetes mellitus – apixaban – oral direct factor Xa inhibitors


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Diabetology Endocrinology Internal medicine
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