Risk of cancers in the treatment of diabetes mellitus by insulin and sulphonylurea drugs

Authors: Marián Mokáň;  Peter Galajda
Authors‘ workplace: I. interná klinika JLF UK a UNM, Martin
Published in: Forum Diab 2022; 11(3): 151-156
Category: Review Article


Type 2 diabetes mellitus is associated with increased risk of some types of carcinomas mainly carcinoma of liver and pancreas, colorectal carcinoma, breast, endometrial and bladder cancers, which is modulated by antidiabetic treatment. Insulin is important growth factor for cancers, but it is not cancerogenic and it does not cause the development of cancers, however it can promote growth of tumors such growth factor. According to clinical studies insulin and sulphonylurea drugs moderately increase cancer risk compared to metformin, which is decreased by their combination with metformin. Insulin analogues, including insulin glargine not increase cancer risk compared to standard insulin and they are considered as safe from oncologic point of view.


type 2 diabetes mellitus – insulin – risk of cancers – sulphonylurea drugs


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