Disorders of carbohydrate metabolism in Cushing‘s syndrome

Authors: Michal Kršek
Authors‘ workplace: III. interní klinika - klinika endokrinologie a metabolizmu1. LF UK a Všeobecná fakultní nemocnice, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA, Praha, Česká republika
Published in: Forum Diab 2014; 3(3): 123-127
Category: Foreign Post


Cushing‘s syndrome (CS) is a rare condition associated with higher secretion of cortisol which causes increased morbidity and mortality, especially cardiovascular. The increased cardiovascular morbidity and mortality is mainly a consequence of metabolic changes which are similar to metabolic syndrome. An important clinical sign of the CS is impaired glucose tolerance presented in more than half of patients. The etiopathogenesis of that is cortisol effect on the tissues and organs resulting in insulin resistance. An active screening is crucial for prognosis of patients with impaired glucose metabolism as well as early treatment and strict diabetic control. Some of these changes persist after CS healing, therefore, for better prognosis it is necessary consistently to search for these patients and intervene if needed. The article presents a review of current knowledge about these changes especially focused on diabetes mellitus in CS, its etiopathogenesis, clinical aspects and treatment.

Key words:
Cushing‘s syndrome – diabetes mellitus – metabolic disorders – pathogenesis


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Diabetology Endocrinology Internal medicine
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