Metabolic syndrome and liver

Authors: Tomáš Koller
Authors‘ workplace: V. interná klinika LF UK a UN Bratislava, Nemocnica Ružinov, prednosta prof. MUDr. Juraj Payer, PhD., FRCP
Published in: Forum Diab 2014; 3(3): 149-153
Category: Topic


In addition to traditionally recognized factors affecting the liver (alcohol, viruses, etc.), the presence of the metabolic syndrome causes various liver lesions. They range from simple steatosis, which is considered a benign lesion, to steatohepatitis, which progresses to liver fibrosis and cirrhosis. Each of the components of the metabolic syndrome in isolation can cause liver damage. The presence of several of these components increases the degree of damage leading potentially to cirrhosis, end-stage liver disease and hepatocellular carcinoma. At the stage of liver cirrhosis specific liver lesions caused by the metabolic syndrome are no more present, therefore the etiology of cirrhosis is often considered as cryptogenic. Metabolic syndrome is also a factor that worsens the prognosis of alcoholic liver disease and chronic hepatitis C. We are currently witnessing a worldwide epidemic of the metabolic syndrome and associated liver injury becomes the most prevalent liver disease. In addition, the presence of liver injury markers increases the risk of progression of the metabolic syndrome itself and also increases the risk of cardiovascular events.

Key words:
end-stage liver disease – hepatocellular carcinoma – liver cirrhosis – liver – steatohepatitis –liver steatosis


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