Kidney transplantation and metabolic syndrome


Authors: Ivana Dedinská 1;  Juraj Miklušica 1;  Ľudovít Laca 1;  Blažej Palkoci 1;  Denisa Osinová 2;  Pavel Makovický 3;  Peter Galajda 3;  Marián Mokáň 3
Authors‘ workplace: Chirurgická klinika a transplantačné centrum, Jesseniova LF UK a UN Martin 1;  Klinika anesteziológie a intenzívnej medicíny, Jesseniova LF UK a UN Martin 2;  I. interná klinika, Jesseniova LF UK a UN Martin 3
Published in: Forum Diab 2016; 5(2): 94-98
Category: Topic

Overview

Aims:
The metabolic syndrome developed after kidney transplantation is the result of several factors which are identical with the risk factors in normal population, however, also some factors typical for the transplanted patients – especially the effects of immunosuppressive therapy.

Material and Methods:
In the group of 268 patients after kidney transplantation, which had no type 1 or type 2 diabetes mellitus before transplantation, we identified patients with metabolic syndrome(based on IDF criteria), 12 months from the kidney transplantation. In all patients, we recorded the following parameters: age at the time of transplantation, type of immunosuppression, waist measure, the value of triacylglycerols, the value of HDL cholesterol, presence of arterial hypertension, and the value of glycaemia in fasting state (or presence of diabetes mellitus). The group of patients was divided into the control group and the group of patients with metabolic syndrome.

Results:
The average age of patients was 46.1 ± 11.6 years. The control group included 149 patients (55.6 %), and we identified the metabolic syndrome in 119 patients (44.4 %). The patients with metabolic syndrome were significantly older (p < 0.0001), had significantly larger waist (both the entire group and the males and females) p < 0.0001. The females with metabolic syndrome had significantly lower value of HDL-cholesterol (p = 0.0013), and significantly higher number of patients with metabolic syndrome had hyperglycaemia in fasting state or diabetes mellitus (p = 0.0006).

Conclusion:
By controlling the weight and waist, we may identify the risk patients for development of metabolic syndrome after kidney transplantation.

Key words:
immunosuppressive therapy – kidney transplantation – metabolic syndrome


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Labels
Diabetology Endocrinology Internal medicine
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