Atrial fibrillation and metformin treatment

Authors: Andrej Dukát 1;  Milan Kriška 2;  Ján Kyselovič 1;  Juraj Payer 1
Authors‘ workplace: V. interná klinika LF UK a UNB, Nemocnica Ružinov, Bratislava 1;  Ústav farmakológie a klinickej farmakológie LF UK v Bratislave 2
Published in: Forum Diab 2023; 12(1): 52-54


Last december Cell Reports Medicine brought significant paper, showing to metformin as a candidate drug for the patients with atrial fibrillation. Using the active comparator, a new design analysis of large-scale longitudinal electronic health record data, metformin use is significantly associated with a reduced risk of atrial fibrillation odds ratio: OR 0,48 (95% CI 0,36–0,54; p < 0,001) compared with standard treatment for diabetes. Metformin showed its benefits also among patients with infection of COVID-19. From its discovery one hundred years ago new data shows new indication for the clinical practice.


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Diabetology Endocrinology Internal medicine
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