Where are we and where are we headed in the prevention of atherosclerosis in patients with type 2 diabetes

Authors: Ivan Tkáč
Authors‘ workplace: Excelentný tím pre výskum aterosklerózy (EXTASY), IV. interná klinika UPJŠ LF a UN LP, Košice
Published in: Forum Diab 2023; 12(1): 46-51


Complications of atherosclerosis, namely coronary heart disease, cerebrovascular ischemia and peripheral artery disease, are a major cause of morbidity and mortality in patients with type 2 diabetes. Significant success have been achieved in atherosclerosis prevention in diabetes with multifactorial interventions targeting risk factors for atherosclerosis. Multifactorial interventions have halved the risk of developing cardiovascular events. Additional contributions in reducing cardiovascular mortality have been made by antidiabetic agents that have additive effects on atherosclerosis progression or treatment of heart failure, such as GLP-1 receptor agonists and SGLT2 inhibitors, respectively. The goals that previous pharmacological interventions have failed to achieve sufficiently are bigger weight reduction and reduction of triacylglyceride levels. With respect to weight reduction, high-dose GLP-1 receptor agonists or dual GLP-1/GIP receptor agonist treatment is promising. New classes of drugs that will be able to reduce triglyceride levels more significantly are also currently under development.


obesity – triglycerides – Atherosclerosis – type 2 diabetes – GLP-1 receptor agonists


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