Obesity as a cause of cardio-nephro-hepato-metabolic diseases


Authors: Ubomíra Fábryová 1,2,3
Authors‘ workplace: MetabolKLINIK s. r. o., Ambulancia pre diabetológiu, poruchy látkovej premeny a výživy, MED PED centrum, Bratislava 1;  Biomedicínske centrum Slovenskej Akadémie Vied, Bratislava 2;  Vysoká škola zdravotníctva a sociálnej práce sv. Alžbety, Inštitút prevencie a intervencie, Bratislava 3
Published in: Forum Diab 2023; 12(1): 11-18
Category:

Overview

Visceral obesity with endocrine dysfunction of adipose tissue and chronic adipogenic and vascular (systemic) subclinical inflammation, insulin resistance, oxidative stress significantly influence the development of cardiometabolic, renal, hepatic and other obesity comorbidities. In addition to genetic predisposition, risky lifestyle (excessive caloric intake, physical inactivity, sedentary life), aging (senescence), intestinal microbiota dysbiosis, chronic infections, lack of sleep and xenobiotics also contribute to the development of the mentioned disorders. For a better understanding, as well as the development of new preventive and treatment strategies, we need to identify and characterize the mechanisms underlying the relationship between obesity and its associated chronic diseases. A breakthrough years ago was the discovery that adipose tissue is an active endocrine organ producing protein hormones and a number of other substances with an endocrine, paracrine, or autocrine effect. These substances are significantly involved in the regulation of glucose and lipid metabolism, food intake, modulation of immune and inflammatory processes. Many of these may represent the sought-after links between adipose tissue dysfunction in obesity and obesity-related cardio-metabolic, renal, and hepatic diseases.

Keywords:

liver diseases – cardiovascular diseases – insulin resistance – chronic subclinical inflammation – dysfunctional adipose tissue – kidney diseases – visceral obesity


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Labels
Diabetology Endocrinology Internal medicine
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