Ten years of treatment of type 2 diabetes mellitus by gliflozins

Authors: Peter Galajda;  Matej Samoš;  Tomáš Bolek;  Simona Horná;  Marián Mokáň
Authors‘ workplace: I. interná klinika JLF UK a UNM, Martin
Published in: Forum Diab 2023; 12(2): 76-83


Sodium-glucose co-transporter 2 (SGLT2) inhibitors, gliflozins are a modern class of diabetic medications which are used ten years in the treatment of type 2 diabetes mellitus. Apart from good glycemic control, low risk of hypoglycemia and weight loss, gliflozins have been shown to provide significant cardiovascular and nephroprotective benefit in patients with type 2 diabetes mellitus. Adverse side effects include increased risk of urinary infections, mainly vaginal candidosis euglycemic ketoacidosis, volume depletion with hypotension, which are considered to be a class effect of gliflozins. According to international standards gliflozins can be indicated such drugs of first choice in the treatment of type 2 diabetic patients with high cardiovascular risk.


gliflozins – adverse effect – cardiovascular and nephroprotective benefit – euglycemic ketoacidosis – sodium-glucose co-transporter 2 (SGLT2) inhibitors- type 2 diabetes mellitus – urinary infections – vaginal candidosis – volume depletion with hypotension


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